Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

René de Waal Malefyt, J S Abrams, B Bennett et al. · The Journal of Experimental Medicine · 1991 · 3.8K citations · Full text

Life Sciences, Immunology, Immunoregulation +10

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector

Mark A. Kay, Catherine S. Manno, Margaret V. Ragni et al. · Nature Genetics · 2000 · 1K citations

Life Sciences, Genetics, Molecular Biology +14

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

Hervé Groux, Mike Bigler, J E de Vries et al. · The Journal of Experimental Medicine · 1996 · 774 citations · Full text

Life Sciences, Immunology, Adaptive Immunity +13

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Richard O. Snyder, Carol H. Miao, G. Patijn et al. · Nature Genetics · 1997 · 585 citations

Pharmacy, Genetics, Molecular Biology +13

Adeno-associated virus vectors can be efficiently produced without helper virus

Takashi Matsushita, SS Elliger, CA Elliger et al. · Gene Therapy · 1998 · 495 citations

Life Sciences, Biotechnology, Molecular Biology +11