Journal of Agricultural and Food Chemistry · 2012 · 24 citations · 34 references
MedicineImmunologyPharmacologyAllergyImmunopharmacologyInflammationAllergic DiseaseAnti-inflammatory PharmacologyCytokine BiologyImmunomodulatory DrugsInflammation PharmacologyInflammatory Cell ResponsesAirway Inflammation ModulationAllergic Airway InflammationAllergic Inflammation PharmacologyAsthma ModelsAsthma PathophysiologyAsthmatic Airway InflammationMurine ModelsTissue Eosinophilia
This study aimed to determine whether brazilin exhibits anti-inflammatory effects that inhibit T helper cell type II (T(H)2) responses and whether it suppresses allergic inflammation reactions in a murine model of asthma. We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Following the intratracheal instillation of brazilin in ovalbumin (OVA)-immunized mice, we found that brazilin-treated mice exhibited decreases in the release of IL-4, IL-5, IL-13, eotaxin-1, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF); inhibited T(H)2 functioning via a decrease in IL-4 production; and exhibited attenuation of OVA-induced lung eosinophilia, airway hyperresponsiveness, and airway remodeling. These results suggest that brazilin exhibits anti-T(H)2 effects both in vitro and in vivo and may possess therapeutic potential for allergic diseases.
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The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
I‐Cheng Ho, Martin R. Hodge, John W. Rooney et al. · Cell · 1996 · 667 citations · Full text
Rhonda H. Wilson, Gregory S. Whitehead, Hideki Nakano et al. · American Journal of Respiratory and Critical Care Medicine · 2009 · 400 citations · Full text