Organic Process Research & Development · 2011 · 37 citations · 5 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryPharmaceutical ManufacturingSynthetic Medicinal ChemistryNatural Product DerivatizationNatural Product Drug DiscoverySafer Chemical SynthesisDrug Candidate OptimizationNatural Product SynthesisPharmaceutical Compound ProductionReagent ScreeningSynthetic Drug Production
The development of a synthetic process for ( S, S )-reboxetine succinate, a candidate for the treatment of fibromylagia, is disclosed from initial scale-up to deliver material for registrational stability testing through to commercial route evaluation and subsequent nomination. This entailed evaluation of several alternative routes to result in what would have been a commercially attractive process for launch of the compound.
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