Progestational Effectiveness of 19-nor-Ethinyl-Testosterone by Oral Route in Women

Abstract

It is clear from the foregoing observations that 10 mg nor-ethisterone given twice daily represents a reproducibly effective dose in women for the production of marked progestational changes in the endometrium. The data suggest that very probably one half this dose will not be effective. The comparably effective dose of ethinyl tes-tosterone (ethisterone) would be about 4 times higher(4). Thus the comparative values agree reasonably well in rabbit, monkey, and man(2,3).