Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

Wenhui Wang, EQ Wang, JP Balthasar · Clinical Pharmacology & Therapeutics · 2008 · 954 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

Michael M. Schmidt, K. Dane Wittrup · Molecular Cancer Therapeutics · 2009 · 574 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

Dhaval K. Shah, Alison Betts · Journal of Pharmacokinetics and Pharmacodynamics · 2011 · 417 citations

Pharmacy, Pharmacokinetics, Pharmacology +10

Man versus Beast: Pharmacokinetic Scaling in Mammals

Joyce Mordenti · Journal of Pharmaceutical Sciences · 1986 · 390 citations

Pharmacy, Pharmacokinetics, Pharmacology +12