Plasma leptin concentrations and OB gene expression in subcutaneous adipose tissue are not regulated acutely by physiological hyperinsulinaemia in lean and obese humans

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

David R. Matthews, J P Hosker, A. Rudenski et al. · Diabetologia · 1985 · 31.4K citations · Full text

Medicine, Endocrinology, Physiology +17

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Robert V. Considine, Madhur K. Sinha, Mark L. Heiman et al. · New England Journal of Medicine · 1996 · 6.3K citations

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Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

L. Arthur Campfield, Françoise J. Smith, Yves Guisez et al. · Science · 1995 · 3.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Transient increase in obese gene expression after food intake or insulin administration

Régis Saladin, Piet De Vos, Michele Guerre-Millot et al. · Nature · 1995 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17