Metabolism and excretion of aminopyrine in man.

Abstract

The metabolism and urinary excretion of aminopyrine in man were examined after an oral administration of drug solution. The metabolites were identified and measured quantitatively by gas chromatography and gas chromatography-mass spectrometry. For the microanalysis of metabolite, mass fragmentography was applied. It was clarified that a new metabolite, 4-formylaminoantipyrine, was detected in all cases and it must be noticed as an important metabolite. It was also meaningful that the individual difference among subjects in their urinary excretion behavior of aminopyrine was remarkable beyond our expectations.