Studies on Drug Metabolism by Use of Isotopes XXVII: Urinary Metabolites of Rutin in Rats and the Role of Intestinal Microflora in the Metabolism of Rutin

Shigeo Baba, Takashi Furuta, Minoru Fujioka, +1

Journal of Pharmaceutical Sciences

BiochemistryMedicineIntestinal MicrofloraPhysiologyToxicology +7

Identification and Quantitative Determination of Fentanyl Metabolites in Patients by Gas Chromatography-Mass Spectrometry 

Tsuyoshi Goromaru, Hiroshi Matsuura, Nozomu Yoshimura, +5

Anesthesiology

FentanylQuantitative DeterminationMetabolomic ProfilingPharmacotherapyMedicinal Chemistry +26

High-affinity [3H]6-nitroquipazine binding sites in rat brain

Kenji Hashimoto, Tsuyoshi Goromaru

European Journal of Pharmacology

NeurophysiologyMedicineNeurotransmitterNeuropharmacologyNeuroscience +5

Quantitative determination of hydrazines berived from isoniazid in patients. I.

ATSUKO NODA, Tsuyoshi Goromaru, Kenji Matsuyama, +3

Journal of Pharmacobio-Dynamics

Medicinal ChemistryPharmaceutical ScienceHydrazine FormationPharmacological StudyPharmacology +13

In vivo formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. I.

ATSUKO NODA, Tsuyoshi Goromaru, NOBUO TSUBONE, +2

Chemical and Pharmaceutical Bulletin

Molecular PharmacologyN-methyl Side ChainPharmacological StudyBiochemistryMedicine +9

Effects of benzylpiperazine derivatives on the neurotoxicity of 3,4-methylenedioxymethamphetamine in rat brain

Kenji Hashimoto, Harumi Maeda, Tsuyoshi Goromaru

Brain Research

Psychoactive DrugNeurophysiologyBenzylpiperazine DerivativesMedicinePsychopharmacology +9

Metabolism and excretion of aminopyrine in man.

Tsuyoshi Goromaru, ATSUKO NODA, Kenji Matsuyama, +1

Chemical and Pharmaceutical Bulletin

Mass FragmentographyPharmacological StudyToxicologyClinical ChemistryHuman Metabolism +16

A new metabolite of aminopyrine (aminophenazone) in man, 4-formylaminoantipyrine.

Sadao Iguchi, Tsuyoshi Goromaru, ATSUKO NODA

Chemical and Pharmaceutical Bulletin

Authentic SampleGas ChromatogramPharmacotherapyExperimental PharmacologyMolecular Pharmacology +17

Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine.

ATSUKO NODA, NOBUO TSUBONE, MARI MIHARA, +2

Chemical and Pharmaceutical Bulletin

Rabbit Liver SlicesBiosynthesisEngineeringBiochemistryMedicine +9

Identification of isopropylantipyrine metabolites in rat and man by using stable isotope tracer techniques.

Tsuyoshi Goromaru, Hiroshi Matsuura, Takashi Furuta, +1

Chemical and Pharmaceutical Bulletin

Minor MetabolitesBiochemistryMedicineMass SpectrometryMetabolomic Profiling +13