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MedicineGeneticsOncologyCarcinogenesisMolecular OncologyNeoplasiaHepatocellular CarcinomaLiver CancerMalignant NeoplasmsMyc Family OncogenesOncogene ActivationOncogene MutationsHepatocellular Carcinoma PathogenesisOncogenic Driver MutationsOncogenic DysregulationOncogenic Myc SignalingP53 MutationTransgenic Mice
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George M. Church, W Gilbert · Proceedings of the National Academy of Sciences · 1984 · 8.2K citations · Full text
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
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Medicine, Cancer Biology, Oncology +12