Concepedia

Treatment of Ulcerative Colitis with a Humanized Antibody to the α <sub>4</sub> β <sub>7</sub> Integrin

Brian G. Feagan, Gordon R. Greenberg, Gary Wild, Richard N. Fedorak, Pierre Paré, John WD McDonald, Réjean Dubé, Albert Cohen, A. Hillary Steinhart, Steven B. Landau,

New England Journal of Medicine · 2005 · 689 citations · 20 references

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Abstract

In this short-term study, MLN02 was more effective than placebo for the induction of clinical and endoscopic remission in patients with active ulcerative colitis.

References

20

Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis

Kenneth W. Schroeder, William J. Tremaine, Duane M. Ilstrup · New England Journal of Medicine · 1987 · 3K citations

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

Filip Baert, Maja Noman, Séverine Vermeire et al. · New England Journal of Medicine · 2003 · 2K citations · Full text

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

C Berlin, Ellen L. Berg, Michael Briskin et al. · Cell · 1993 · 1.4K citations

, , +9

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +12

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

David H. Miller, Omar Khan, William Sheremata et al. · New England Journal of Medicine · 2003 · 1.2K citations · Full text