Concepedia

Stereoselective Total Synthesis of FD-891

J. S. Yadav, Sukant Kishore Das, Gowravaram Sabitha

The Journal of Organic Chemistry · 2012 · 27 citations · 23 references

DOI

Concepts

Abstract

FD-891, a structurally unique 16-membered macrolide having anticancer activity, was synthesized according to a strategy employing asymmetric allylation, Prins cyclization, cross-metathesis reaction, Yamaguchi lactonization, and Julia-Kocienski olefination.

References

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