Effect of Injection of Rabbit Leucocytes into Neonatal Rabbits on Subsequent Lymph Node Cell Transfer.

Abstract

1. Newborn rabbits were injected with leucocytes obtained from adult rabbits which were prospective donors of lymph node cells. When antigen-incubated lymph node cells from these donors were transferred to young rabbits 1-2 1/2 months later, agglutinins failed to appear, or did so in low titer. This suppression of transferred lymph node cells indicated that tissues of newborn rabbits had reacted to antigens of leucocytes of donor animals. 2. Transfer of lymph node cells incubated in vitro with Shigella-trypsin filtrate to uninjected newborn rabbits (1-11 days of age) resulted in the appearance of anti-Shigella agglutinins.