Concepedia

Palladium-Catalyzed <i>Ortho</i>-Arylation of Carbamate-Protected Estrogens

Robin B. Bedford, Peter B. Brenner, Steven J. Durrant, Timothy Gallagher, Carolina Méndez‐Gálvez, Michelle Montgomery

The Journal of Organic Chemistry · 2016 · 12 citations · 13 references

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Concepts

Abstract

The palladium-catalyzed ortho-arylation of diethyl carbamate-protected estrone and estriol with aryl iodides gives the 2-arylated analogues. Subsequent removal of the carbamate directing group furnishes 2-arylated estrone, estradiol, or estriol depending on the method used.

References

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A Highly <i>Para</i>‐Selective Copper(II)‐Catalyzed Direct Arylation of Aniline and Phenol Derivatives

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Synthesis of Dibenzofurans via Palladium-Catalyzed Phenol-Directed C–H Activation/C–O Cyclization

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Robin B. Bedford, M. Limmert · The Journal of Organic Chemistry · 2003 · 210 citations

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MEI HONG ZHANG, Hong Man, Xiao Zhao et al. · Biomedical Reports · 2013 · 121 citations · Full text

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