Synthesis of 2,6′-Dioxo-1′,5′,6′,7′-tetrahydrospiro[indoline-3,4′-pyrazolo[3,4-<i>b</i>]pyridine]-5′-carbonitriles via a One-Pot, Three-Component Reaction in Water

Abstract

A one-pot, three-component condensation reaction of an isatin, aminopyrazole, and alkyl cyanoacetate in water to give 2,6'-dioxo-1',5',6',7'-tetrahydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-5'-carbonitrile with good yields, at 90 °C, using a Et(3)N as catalyst, is described.