PubMed · 2009 · 14 citations · 0 references
Life SciencesBiochemistryMicrobiologyMarine MicrobiologyMetabolismMicrobial MetabolismFungal Secondary MetabolitesMarine Microbial MetabolismMetabolite IdentificationMicrobial BiotransformationMicrobial Metabolite ProductionTerpenoid BiosynthesisBioactive Marine MetabolitesDiterpene BiosynthesisMarine Fungal MetabolitesMarine Fungal Secondary MetabolitesMarine Microbial Natural ProductsMarine Microbial Secondary MetabolitesMonoterpene BiosynthesisStructure Elucidation Of Fungal Metabolites
Geraniol (1) is the biogenetic precursor of a number of monoterpenes. We tested various marine-derived microorganisms to determine their ability to biotransform 1. Only Hypocrea sp. was capable of transforming 1 into its oxidized derivative, 1,7-dihydroxy-3,7-dimethyl-(E)-oct- 2-ene (2). The structure of the metabolite obtained was assigned on the basis of detailed spectroscopic data analyses.