Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

K. Jin Kim, Bing Li, Jane Winer et al. · Nature · 1993 · 3.6K citations

Medicine, Cancer Biology, Oncology +14

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

Farida Latif, Kálmán Tory, James R. Gnarra et al. · Science · 1993 · 3K citations

Medicine, Genetics, Molecular Genetics +17

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16