Interferon Induction in Man by a Synthetic Polyanion of Defined Composition

Abstract

SINCE its discovery,1 interferon has been considered to have potential value in the control of virus disease in man. Primary vaccinia infection has been blocked in human beings by preinoculation of skin sites with monkey interferon prepared in tissue culture,2 , 3 and by the use of live-virus-vaccine induction of circulating interferon before vaccinia inoculation.4 Unfortunately, although human interferon can be produced in tissue culture and appears during a variety of naturally occurring and artificially induced virus infections in man – both in serum and in infected tissue – it has not been obtained in quantities sufficient for treatment of naturally occurring . . .