Science · 1965 · 717 citations · 11 references
Life SciencesImmunologyInfectious DiseasesMolecular VirologyPlant VirologyVirologyAntiviral ImmunityInterferon ResponsesPlant VirusesViral InfectionsViral PathogenesisVirus-host InteractionsAntiviral Interferon ResponsesCytopathic EffectsInhibition Of Interferon ResponsesInterferon ProductionInterferon Response To Viral InfectionPh DependenceSindbis Virus InfectionViral Cytopathic Effect
Phytohemagglutinin, an extract of the kidney bean, Phaseolus vulgaris, induces in human leukocyte cultures an inhibitor of the cytopathic effects of Sindbis virus. The physicochemical and biological properties of this virus-inhibitor are similar to those of interferon induced by Newcastle disease virus, except for an instability at pH 2 and 10 and at 56 degrees C.
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Inhibition of Virus Multiplication by Foreign Nucleic Acid
Z. Rotem, Robert A. Cox, A. Isaacs · Nature · 1963 · 140 citations