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Tolerance Specificity and the Immune Response to Lactic Dehydrogenase Isoenzymes
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1967
Year
Immune ToleranceHumoral ResponseImmunologyImmunodominanceAntigen ProcessingImmunotherapyTolerance SpecificityAntibody EngineeringAntibody SpecificityAlcohol DehydrogenasesAldehyde DehydrogenaseAllergyAutoimmune DiseaseAutoimmunitySelf-toleranceHumoral ImmunityTolerance InductionCellular EnzymologyPathogenesisTransmission MechanismImmunomodulationMetabolismMedicine
Whereas it seems well established that antibody production is due to monospecific effector cells, the transmission mechanism from individual antigenic determinants to individual antibody producing cells and their production units is not clearly understood. Immunochemical work on the specificity of antigen in the course of the immune response is difficult to reconcile with a simple linear transmission. Phenomena like the hapten-carrier effect (see below), antigenic competition (Adler, 1964), original antigenic sin (cf. Fazekas de St. Groth and Webster, 1966) and tolerance specificity as distinct from antibody specificity (Austin and Nossal, 1966), all suggest that the process of immune initiation is a complex one.