Concepedia

The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

Sang Wun Kim, Reyhaneh Lahmy, Chelsea Riha, Challeng Yang, Brad L. Jakubison, Jaco van Niekerk, Claudio Staub, Yifan Wu, Keith P. Gates, Duc Si Dong,

Pancreas · 2015 · 50 citations · 49 references

DOIFull text

Open access

Abstract

Human PDA cells retain a high degree of plasticity, which can be exploited to induce a quiescent acinar cell state with reduced tumorigenic potential. Moreover, bHLH activity is a critical node coordinately regulating human PDA cell growth versus cell fate.

References

49

Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group

Malcolm J. Moore, David Goldstein, John Hamm et al. · Journal of Clinical Oncology · 2007 · 3.8K citations

A gene atlas of the mouse and human protein-encoding transcriptomes

Andrew I. Su, Tim Wiltshire, Serge Batalov et al. · Proceedings of the National Academy of Sciences · 2004 · 3.5K citations · Full text

, , +19

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Sunil R. Hingorani, Emanuel F. Petricoin, Anirban Maitra et al. · Cancer Cell · 2003 · 2.5K citations · Full text

, , +8

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Eric A. Collisson, Anguraj Sadanandam, Peter Olson et al. · Nature Medicine · 2011 · 1.9K citations · Full text

, , +7

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

Carmen Guerra, Alberto J. Schuhmacher, Marta Cañamero et al. · Cancer Cell · 2007 · 1.2K citations · Full text

, , +10