Synthesis of Pyrazines from Rhodium-Catalyzed Reaction of 2<i>H</i>-Azirines with <i>N</i>-Sulfonyl 1,2,3-Triazoles

Abstract

An efficient synthetic route to a wide range of trisubstituted pyrazines is developed from Rh-catalyzed reaction of 2H-azirines with N-sulfonyl-1,2,3-triazoles through the elimination of nitrogen molecule and arylsulfinic acid. The present reaction proceeds through formation of in situ generated dihydropyrazines.