Studies on the chinese crude drug "forsythiae fructus." VI. The structure and antibacterial activity of suspensaside isolated from forsythia suspensa.

Abstract

A new caffeoyl glycoside of β, 3, 4-trihydroxyphenethyl alcohol, designated as suspensaside (1), was isolated from the fruits of Forsythia suspensa VAHL (Oleaceae). The structure of 1 was established as DL-β, 3, 4-trihydroxyphenethyl-O-α-L-rhamnopyranosyl-(1→6)-4-O-caffeoyl-β-D-glucopyranoside on the basis of analysis of the carbon-13 nuclear magnetic resonance spectrum and chemical evidence. Compound 1 exhibited antibacterial activity against Staphylococcus aureus TERASHIMA. with MIC 4.1 mM (2.6 mg/ml).