Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation

Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys

M. Innes Asher, Stephen Montefort, Bengt Björkstén et al. · The Lancet · 2006 · 4.2K citations

Asthma, Allergy, Pediatric Epidemiology +8

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

Major Predisposing Factor, Common Loss-of-function Variants, Atopic Dermatitis +8

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis

Julia Gittler, Avner Shemer, Mayte Suárez‐Fariñas et al. · Journal of Allergy and Clinical Immunology · 2012 · 931 citations

Inflammation, Progressive Activation, Atopic Dermatitis +7

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 660 citations

Allergy, Atopic Dermatitis, Genetic Disorder +11

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

Hua-Chen Chang, Sarita Sehra, Ritobrata Goswami et al. · Nature Immunology · 2010 · 561 citations · Full text

Inflammation, Autoimmune Disease, Allergy +12