Concepedia
Cellular Physiology and Biochemistry · 2016 · 51 citations · 37 references
Open access
This study suggests that EW-7197 exhibits potential as a treatment for liver fibrosis because it inhibits HIF1α-induced TGF-β signaling.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text
Genetics, Molecular Biology, Hif-1 Subunits +21
Liver fibrosis
Ramón Bataller · Journal of Clinical Investigation · 2005 · 1.5K citations · Full text
Inflammation, Molecular Pharmacology, Liver Fibrosis +13
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Debra F. Higgins, Kuniko Kimura, Wanja M. Bernhardt et al. · Journal of Clinical Investigation · 2007 · 963 citations · Full text
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
Christophe Corpechot, Véronique Barbu, Dominique Wendum et al. · Hepatology · 2002 · 467 citations
Liver Fibrosis, Pathology, Cholangiopathies +23
Transforming Growth Factor-β1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro
Aki Kaimori, James J. Potter, Jun-ya Kaimori et al. · Journal of Biological Chemistry · 2007 · 348 citations · Full text