Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

Darren E. Richard, Edurne Berra, Emmanuel Gothié et al. · Journal of Biological Chemistry · 1999 · 784 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Intramuscular desferrioxamine in patients with Alzheimer's disease

D. R. Crapper McLachlan · The Lancet · 1991 · 761 citations

Medicine, Neurology, Pharmacology +12

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

Deepinder Kaur, Ferda Yantiri, Subramanian Rajagopalan et al. · Neuron · 2003 · 619 citations · Full text

Life Sciences, Neuroscience, Pharmacology +10

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

Julio Salazar, Natalia Mena, Stéphane Hunot et al. · Proceedings of the National Academy of Sciences · 2008 · 410 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Increased iron‐related MRI contrast in the substantia nigra in Parkinson's disease

Jay M. Gorell, Roger J. Ordidge, Garth G. Brown et al. · Neurology · 1995 · 321 citations

Medicine, Neurology, Neuroscience +17