Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non‐ Sickle dialysis patients

Louise Møldrup Nielsen, Florence Canouï‐Poitrine, Jean‐Philippe Jaïs, Djamal Dahmane, Pablo Bartolucci, Bouteina Bentaarit, Justine Gellen‐Dautremer, Philippe Rémy, Tomek Kofman, Marie Matignon,

British Journal of Haematology · 2016 · 43 citations · 9 references

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Abstract

We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft.

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