Concepedia

Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

Jingjing Zhang, Shufang Zhou, Q. Wang, Jiankuo Guo, Haoyang Liang, J.-B. Deng, Wencan He

Neuroscience · 2016 · 83 citations · 32 references

DOI

Concepts

References

32

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Dave Morgan, David M. Diamond, Paul E. Gottschall et al. · Nature · 2000 · 1.5K citations

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

, , +14

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 994 citations

, , +16

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

Michael H. Yan, Xinglong Wang, Xiongwei Zhu · Free Radical Biology and Medicine · 2012 · 724 citations

, , +17

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Masuo Ohno, Evgeny A. Sametsky, Linda H. Younkin et al. · Neuron · 2004 · 563 citations · Full text

, , +16