mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

Vicente E. Torres, Arlene B. Chapman, Olivier Devuyst et al. · New England Journal of Medicine · 2012 · 1.5K citations · Full text

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

Jonathan M. Shillingford, Noel Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences · 2006 · 790 citations · Full text

Renal Pathology, Renal Cystogenesis, Renal Inflammation +19

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

D J Kwiatkowski · Human Molecular Genetics · 2002 · 679 citations · Full text

Tsc Hamartomas, Cell Death, Pathology +19

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

Gerd Walz, Klemens Budde, Marwan Mannaa et al. · New England Journal of Medicine · 2010 · 571 citations · Full text

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

Andreas L. Serra, Diane Poster, Andreas D. Kistler et al. · New England Journal of Medicine · 2010 · 554 citations · Full text

Renal Pathology, Pathology, Glomerulonephritis +16