Concepedia

Epistasis between COMT Val158Met and DRD3 Ser9Gly polymorphisms and cognitive function in schizophrenia: genetic influence on dopamine transmission

Alexandre Andrade Loch, Martinus Theodorus van de Bilt, Danielle Soares Bio, Carolina Martins do Prado, RAFAEL TEIXEIRA DE SOUSA, Leandro Valiengo, Ricardo Alberto Moreno, Marcus V. Zanetti, Wagner F. Gattaz

Brazilian Journal of Psychiatry · 2015 · 15 citations · 29 references

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Abstract

Combined genetic polymorphisms related to dopamine neurotransmission might influence executive function in schizophrenia. Looking at the effects of multiple genes on a single disease trait (epistasis) provides a comprehensive and more reliable way to determine genetic effects on endophenotypes.

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