Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT - Concepedia

Concepedia

Publication | Open Access

Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT

DOI Full Paper Access

60

Citations

14

References

2016

Year

Hui Ren, Jianjun Mu, Jingjing Ma, Jie Gong, Jing Li, Jiawen Wang, Tianlin Gao, Peng Zhu, Shikang Zheng, Jing Xie,

Cellular Physiology and Biochemistry

Abstract

Selenium protected against homocysteine-induced dysfunction and apoptosis of endothelial cells through AKT pathway. The observations may provide novel therapeutic opportunities in the treatment of CVD.

References

	Year	Citations
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler, Nature Endothelial CellsCellular PhysiologyOxidative StressInflammationAngiogenesis	1999	3.6K
Mesenchymal Stem Cells Enhance Angiogenesis in Mechanically Viable Prevascularized Tissues via Early Matrix Metalloproteinase Upregulation Cyrus M. Ghajar, Katherine S. Blevins, Christopher C.W. Hughes, Tissue Engineering	2006	222
Selenium supplementation for the primary prevention of cardiovascular disease Karen Rees, Louise Hartley, Camilla Day, Cochrane Database of Systematic Reviews	2013	169
Wall Stiffness Suppresses Akt/eNOS and Cytoprotection in Pulse-Perfused Endothelium Xinqi Peng, Saptarsi M. Haldar, Shailesh Deshpande, Hypertension	2003	143
Dysfunction of Nitric Oxide Mediation in Isolated Rat Arterioles With Methionine Diet–Induced Hyperhomocysteinemia Zoltán Ungvári, Pál Pacher, Katalin Rischák, Arteriosclerosis Thrombosis and Vascular Biology	1999	130
Homocysteine and vitamin therapy in stroke prevention and treatment: a review. Bogdan Nicolae Manolescu, Eliza Oprea, Ileana C. Fărcăşanu, Acta Biochimica Polonica B Vitamins StatusCerebrovascular DiseaseHyperlipidemiaHcy BiochemistryOxidative Stress	2010	70
Introduction to next generation of endothelial progenitor cell therapy: a promise in vascular medicine. Dewi Sukmawati, Rica Tanaka PubMed Cell TherapyImmunologyNew GenerationBiomedical EngineeringRegenerative Medicine	2015	68
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling Tingting Yan, Qian Li, X Zhang, Clinical and Experimental Pharmacology and Physiology Vascular DiseaseLipid PeroxidationImmunologyVascular Endothelial GrowthHyperlipidemia	2010	46
Effect of Selenium Deficiency on Nitric Oxide and Heat Shock Proteins in Chicken Erythrocytes Jinxin Zhao, Houjuan Xing, Chunpeng Liu, Biological Trace Element Research Animal PhysiologyBiochemistrySelenium DeficiencyNitric OxidePhysiology	2015	39
Homocysteine Induces Cell Cycle G1 Arrest in Endothelial Cells through the PI3K/Akt/FOXO Signaling Pathway Hongsheng Zhang, En‐Hua Cao, Jing‐Fen Qin Pharmacology	2005	39

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