Concepedia

Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT

Hui Ren, Jianjun Mu, Jingjing Ma, Jie Gong, Jing Li, Jiawen Wang, Tianlin Gao, Peng Zhu, Shikang Zheng, Jing Xie,

Cellular Physiology and Biochemistry · 2016 · 60 citations · 14 references

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Abstract

Selenium protected against homocysteine-induced dysfunction and apoptosis of endothelial cells through AKT pathway. The observations may provide novel therapeutic opportunities in the treatment of CVD.

References

14

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations

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Mesenchymal Stem Cells Enhance Angiogenesis in Mechanically Viable Prevascularized Tissues via Early Matrix Metalloproteinase Upregulation

Cyrus M. Ghajar, Katherine S. Blevins, Christopher C.W. Hughes et al. · Tissue Engineering · 2006 · 222 citations

Selenium supplementation for the primary prevention of cardiovascular disease

Karen Rees, Louise Hartley, Camilla Day et al. · Cochrane Database of Systematic Reviews · 2013 · 169 citations · Full text

Wall Stiffness Suppresses Akt/eNOS and Cytoprotection in Pulse-Perfused Endothelium

Xinqi Peng, Saptarsi M. Haldar, Shailesh Deshpande et al. · Hypertension · 2003 · 143 citations · Full text

Dysfunction of Nitric Oxide Mediation in Isolated Rat Arterioles With Methionine Diet–Induced Hyperhomocysteinemia

Zoltán Ungvári, Pál Pacher, Katalin Rischák et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1999 · 130 citations · Full text