The Antiinflammatory Effects of Methotrexate are Mediated by Adenosine

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

Bruce N. Cronstein, Dwight Naime, Edward Ostad · Journal of Clinical Investigation · 1993 · 678 citations · Full text

Medicine, Immunology, Pharmacology +16

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

Bruce N. Cronstein, Mark Eberle, Harry E. Gruber et al. · Proceedings of the National Academy of Sciences · 1991 · 340 citations

Life Sciences, Cell Biology, Pharmacology +11

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

Carmen J. Allegra, J C Drake, Jacques Jolivet et al. · Proceedings of the National Academy of Sciences · 1985 · 313 citations · Full text

Medicine, Oncology, Pharmacology +7

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5′-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide

Joseph E. Baggott, William H. Vaughn, B B Hudson · Biochemical Journal · 1986 · 205 citations · Full text

Life Sciences, Pharmacology, Biochemical Pharmacology +6

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.

Carmen J. Allegra, Khánh Hoàng, Grace Chao Yeh et al. · Journal of Biological Chemistry · 1987 · 142 citations · Full text

Medicine, Biochemistry, Pharmacology +14