Concepedia

Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors

Andrea Muscat, Dean Popovski, W. Samantha N. Jayasekara, Fernando J. Rossello, Melissa Ferguson, Kieren D. Marini, Muhammad Alamgeer, Elizabeth M. Algar, Peter Downie, D. Neil Watkins,

Clinical Cancer Research · 2016 · 61 citations · 33 references

DOIFull text

Open access

Abstract

Low-dose HDACi treatment can terminally differentiate MRT tumor cells and reduce their ability to self-renew. The use of low-dose HDACi as a novel therapeutic approach warrants further investigation. Clin Cancer Res; 22(14); 3560-70. ©2016 AACR.

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