Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

K M Tewey, G L Chen, Eric M. Nelson et al. · Journal of Biological Chemistry · 1984 · 887 citations · Full text

Alkaloids of Ochrosia elliptica Labill.¹

Sidney Goodwin, A. F. Smith, E. C. Horning · Journal of the American Chemical Society · 1959 · 231 citations

Altmetrics, Bioorganic Chemistry, Engineering +14

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

Caroline A. Austin, Sandhiya Patel, Katsuhiko Ono et al. · Biochemical Journal · 1992 · 170 citations · Full text

Cleavage Specificity, Molecular Biology, Chemical Biology +16

Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation

Huimin Wang, Yong Mao, Allan Y. Chen et al. · Biochemistry · 2001 · 154 citations

Thiol-reactive Quinones, Chromatin, Genome Instability +13

Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.

Stacie J. Froelich-Ammon, Marcia W. Patchan, Neil Osheroff et al. · Journal of Biological Chemistry · 1995 · 138 citations · Full text