Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, Aviva Breuer, Roger G. Pertwee et al. · Science · 1992 · 5.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Benjamin F. Cravatt, Dan K. Giang, Stephen P. Mayfield et al. · Nature · 1996 · 2.1K citations

Life Sciences, Biochemistry, Neuroscience +14

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Vincenzo Di Marzo, Angelo Fontana, Hugues Cadas et al. · Nature · 1994 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

A second endogenous cannabinoid that modulates long-term potentiation

Nephi Stella, Paul Schweitzer, Daniele Piomelli · Nature · 1997 · 1.5K citations · Full text

Medicine, Neuroscience, Pharmacology +13