Antiasthmatic Activity of the Second-Generation Phosphodiesterase 4 (PDE4) Inhibitor SB 207499 (Ariflo) in the Guinea Pig

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

J. M. van Rossum · PubMed · 1963 · 1.2K citations

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4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain

Ulrich Schwabe, M. Miyake, Y Ohga et al. · Molecular Pharmacology · 1976 · 219 citations

Medicine, Neurobiology, Pharmacology +14

Antigen‐Induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐Pigs Pattern of Response in Relation to Immunization Regimen

Per Andersson · Allergy · 1980 · 175 citations

Life Sciences, Immunology, Allergy +8

Rolipram in Major Depressive Disorder: Results of a Double-Blind Comparative Study with Imipramine

G. Hebenstreit, Katrin Fellerer, K. Fichte et al. · Pharmacopsychiatry · 1989 · 157 citations

Medicine, Pharmacology, Pharmacotherapy +17

1,4-Cyclohexanecarboxylates:  Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Siegfried B. Christensen, Aimee M. Guider, Cornelia J. Forster et al. · Journal of Medicinal Chemistry · 1998 · 150 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11