Synthesis and pharmacological evaluation of trifluoromethyl containing 4-(2-pyrimidinylamino)benzamides as Hedgehog signaling pathway inhibitors

Structure of the human smoothened receptor bound to an antitumour agent

Chong Wang, Huixian Wu, Vsevolod Katritch et al. · Nature · 2013 · 458 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant

Tsuyoshi Ishii, Yūji Shimizu, Kosuke Nakashima et al. · European Journal of Pharmacology · 2013 · 44 citations

Medicine, Oncology, Pharmacology +11

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors

Minhang Xin, Liandi Zhang, Feng Tang et al. · Bioorganic & Medicinal Chemistry · 2014 · 35 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold

Yan Lou, Zachary K. Sweeney, A. Kuglstatter et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors

Minhang Xin, Jun Wen, Feng Tang et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12