Publication | Closed Access
Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase
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Citations
30
References
2016
Year
Inhibitory ActivityMedicinal ChemistryDerivative (Chemistry)DerivativesBiochemistryMedicineNatural SciencesChemical DerivativePharmacological AgentNeuropharmacologyDonepezil-based ReactivatorsAgent-inhibited Human AcetylcholinesteraseBetter AbilityRedox ChemistryPharmacologyRedox BiologyVitro Evaluation
Donepezil-based reactivators <bold>1–3</bold> show a better ability (8 fold higher) than pralidoxime to reactivate VX-hAChE, and oxime <bold>2</bold> is 5 to 11 fold more efficient than pralidoxime and HI-6 respectively to reactivate of VX-hBChE.
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