Downregulation of IDH2 exacerbates H₂O₂-mediated cell death and hypertrophy

Abstract

OBJECTIVES: -dependent isocitrate dehydrogenase (IDH2) functions as an antioxidant and anti-apoptotic protein by supplying NADPH to antioxidant systems. METHODS: -induced apoptosis and hypertrophy of H9c2 cardiomyoblasts was markedly exacerbated by small interfering RNA (siRNA) specific for IDH2. RESULTS: . DISCUSSION: -induced apoptosis and hypertrophy of cultured cardiomyocytes by the attenuated IDH2 expression.