RECKONER: read error corrector based on KMC

Abstract

Summary: Presence of sequencing errors in data produced by next-generation sequencers affects quality of downstream analyzes. Accuracy of them can be improved by performing error correction of sequencing reads. We introduce a new correction algorithm capable of processing eukaryotic close to 500 Mbp-genome-size, high error-rated data using less than 4 GB of RAM in about 35 min on 16-core computer. Availability and Implementation: Program is freely available at http://sun.aei.polsl.pl/REFRESH/reckoner . Contact: sebastian.deorowicz@polsl.pl. Supplementary information: Supplementary data are available at Bioinformatics online.