Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity

Derivation and Validation of Toxicophores for Mutagenicity Prediction

Jeroen Kazius, Ross McGuire, Roberta Bursi · Journal of Medicinal Chemistry · 2004 · 656 citations

Pharmacy, Toxicology, Mechanisms Of Toxicity +12

The Benigni / Bossa rulebase for mutagenicity and carcinogenicity - a module of Toxtree

Romualdo Benigni, Cecilia Bossa, Nina Jeliazkova et al. · 2008 · 176 citations

Pharmacy, Bioinformatics, Toxicology +15

A QSAR investigation of the role of hydrophobicity in regulating mutagenicity in the ames test: 1. Mutagenicity of aromatic and heteroaromatic amines in <i>Salmonella typhimurium</i> TA98 and TA100

Asim K. Debnath, Gargi Debnath, Alan J. Shusterman et al. · Environmental and Molecular Mutagenesis · 1992 · 158 citations

Pharmacy, Toxicology, Drug Discovery +12

LeadScope:  Software for Exploring Large Sets of Screening Data

Gulsevin Roberts, Glenn J. Myatt, Wayne P. Johnson et al. · Journal of Chemical Information and Computer Sciences · 2000 · 155 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints

Edwin J. Matthews, Naomi L. Kruhlak, Michael C. Cimino et al. · Regulatory Toxicology and Pharmacology · 2005 · 135 citations

Pharmacy, Genetics, Toxicology +17