Inhibitors of Calmodulin-Dependent Protein Kinase Are Nonspecific Blockers of Voltage-Dependent K+ Channels in Vascular Myocytes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Natural Sciences, Biophysics, Cell Biology +16

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

Hiroshi Tokumitsu, Takashi Chijiwa, Masatoshi Hagiwara et al. · Journal of Biological Chemistry · 1990 · 625 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

The newly synthesized selective Ca2+calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

Mariko Sumi, Kazutoshi Kiuchi, Tomohiko Ishikawa et al. · Biochemical and Biophysical Research Communications · 1991 · 509 citations

Life Sciences, Neuroscience, Pharmacology +14

Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase

Weilong Yuan, Donald M. Bers · American Journal of Physiology-Heart and Circulatory Physiology · 1994 · 230 citations

Life Sciences, Cell Biology, Physiology +17

Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

Mark E. Anderson, Andrew P. Braun, Howard Schulman et al. · Circulation Research · 1994 · 219 citations

Life Sciences, Cell Biology, Physiology +17