TGFβ1‐Smad3‐Jagged1‐Notch1–Slug signaling pathway takes part in tumorigenesis and progress of tongue squamous cell carcinoma

Abstract

The key protein expression in TGFβ1-Smad3-Jagged1-Notch1-Slug signaling pathway significantly correlated with the clinicopathological features of TSCC patients. It's potential as a biomarker and a novel therapeutic target for TSCC patients at risk of metastasis. It may play an irreplaceable role in TSCC progression which may attribute to promoting EMT which enhances cell migration, invasion and metastasis.