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Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

Laura Valls-Lacalle, Ignasi Barba, Elisabet Miró‐Casas, Juan J. Alburquerque-Béjar, Marisol Ruiz‐Meana, Marina Fuertes‐Agudo, Antonio Rodríguez‐Sinovas, David García‐Dorado

Cardiovascular Research · 2015 · 142 citations · 27 references

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Abstract

Succinate dehydrogenase inhibition with malonate at the onset of reperfusion reduces infarct size in isolated mice hearts through reduction in ROS production and mitochondrial permeability transition pore opening.

References

27

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude et al. · Nature · 2014 · 2.7K citations · Full text

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Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

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, , +11

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

Elinor J. Griffiths, Andrew P. Halestrap · Journal of Molecular and Cellular Cardiology · 1993 · 573 citations

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Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

Kerstin Boengler, Denise Hilfiker‐Kleiner, Gerd Heusch et al. · Basic Research in Cardiology · 2010 · 371 citations · Full text