Global translational impacts of the loss of the tRNA modification t6A in yeast

Abstract

Global translational impacts of the loss of the tRNA modification t6A in yeast – INTRODUCTION Modifications of the anticodon stem loop (ASL) of transfer RNA (tRNA) are critical for translational speed and accuracy. As the genetic code is degenerate, most tRNAs decode several codons . Nucleoside modifications ensure that the decoding process is stringent enough to discriminate between closely-related codons and yet relaxed enough to allow decoding of more than (...)