Synergistic Inhibition of Both P2Y<sub>1</sub>and P2Y<sub>12</sub>Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis - Concepedia

Concepedia

Publication | Open Access

Synergistic Inhibition of Both P2Y<sub>1</sub>and P2Y<sub>12</sub>Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis

DOI Full Paper Access

55

Citations

32

References

2016

Year

Thomas Gremmel, Ivan B. Yanachkov, Milka Yanachkova, George E. Wright, Joseph M. Wider, Vishnu Undyala, Alan D. Michelson, Andrew L. Frelinger, Karin Przyklenk

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.

References

	Year	Citations

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