PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non–Small Cell Lung Cancer

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer, Scott S. Tykodi, Laura Q.M. Chow et al. · New England Journal of Medicine · 2012 · 8K citations · Full text

Life Sciences, Immunology, Oncology +17

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 ⁺ T lymphocytes are prognostic factors of human ovarian cancer

Junzo Hamanishi, Masaki Mandai, Masashi Iwasaki et al. · Proceedings of the National Academy of Sciences · 2007 · 1.4K citations · Full text

Medicine, Immunology, Oncology +17

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

Michael R. Green, Stefano Monti, Scott J. Rodig et al. · Blood · 2010 · 1.3K citations · Full text

Medicine, Cancer Biology, Oncology +17

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Tadashi Yokosuka, Masako Takamatsu, Wakana Kobayashi-Imanishi et al. · The Journal of Experimental Medicine · 2012 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

Yuichiro Ohigashi, Masayuki Sho, Yukishige Yamada et al. · Clinical Cancer Research · 2005 · 792 citations · Full text

Medicine, Oncology, Pathology +17