Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Timothy R. Koves, John R. Ussher, Robert C. Noland et al. · Cell Metabolism · 2008 · 2K citations · Full text

Life Sciences, Cell Biology, Physiology +16

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*

Bhaskar Ponugoti, Dong-Hyun Kim, Zhen Xiao et al. · Journal of Biological Chemistry · 2010 · 544 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat

Thorsten P. Degenhardt, Nathan L. Alderson, David D. Arrington et al. · Kidney International · 2002 · 377 citations

Medicine, Nephrology, Pharmacology +11

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

Amy K. Walker, Fajun Yang, Karen Jiang et al. · Genes & Development · 2010 · 353 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

Weijing Cai, Maya Ramdas, Li Zhu et al. · Proceedings of the National Academy of Sciences · 2012 · 321 citations · Full text

Medicine, Endocrinology, Nutritional Sciences +17