Lack of SH3 domain does not imply a more severe clinical course in Ph+ chronic myeloid leukemia patients

Abstract

Philadelphia-positive (Ph+) hematological malignancies are characterized by different BCR-ABL rearrangements. Three breakpoint cluster regions on chromosome 22 have been described: major (M-BCR), involving BCR exons 13 or 14 (e13 and e14, or b2 and b3) and giving origin to protein P210; minor (m-BCR