Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs

Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel.

Neil Desai, Vuong Trieu, Zhiwen Yao et al. · Clinical Cancer Research · 2006 · 1.1K citations

The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

Chaity Chaudhury, Samina Mehnaz, John M. Robinson et al. · The Journal of Experimental Medicine · 2003 · 621 citations · Full text

Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies

Raimund J. Ober, Caius G. Radu, Victor Gheţie et al. · International Immunology · 2001 · 485 citations

Immunocytochemical Technique, Immunology, Immune System +18

Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells

Masaru Yoshida, Steven M. Claypool, Jessica Wagner et al. · Immunity · 2004 · 464 citations · Full text

Signal Transduction, Medicine, Cell Trafficking +9

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs

Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule et al. · The Journal of Immunology · 2003 · 446 citations