Concepedia

Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop

Ikki Sakuma, Seiichiro Higuchi, Masanori Fujimoto, Tomoko Takiguchi, Akitoshi Nakayama, Ai Tamura, Takashi Kohno, Eri Komai, Akina Shiga, Hidekazu Nagano,

The Journal of Clinical Endocrinology & Metabolism · 2015 · 48 citations · 8 references

DOIFull text

Open access

Abstract

We present a case of ectopic ACTH syndrome associated with pheochromocytoma. ACTH up-regulation with paradoxical response to glucocorticoid, possibly through the hypomethylation of the POMC promoter, exacerbated the patient's condition.

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